Lungs and gas exchange
By the end of this chapter you will be able to
- Name the parts of the airway and say what each does
- Explain how alveoli are adapted for gas exchange
- Describe how the chest muscles change the volume of the lungs when breathing in and out
- Interpret data on smoking and lung disease, and describe the effect on the lungs
- [H] Calculate the total surface area from the number and size of alveoli
You should already know
- Diffusion and exchange surfaces (Chapter 3)
- Aerobic respiration uses oxygen (Chapter 10 links back)
Where this leads
- Blood and the circulation carry gases (Chapter 6)
- Respiration in cells (Chapter 10)
- Cancer and cell division (Chapter 4)
GCSE Biology. Content follows the GCSE (9-1) subject content for England (Edexcel and AQA). Content references: Describe the structure of the lungs, trachea, bronchi and alveoli, Explain how alveoli are adapted for the diffusion of oxygen and carbon dioxide, Describe breathing, using the diaphragm and the intercostal muscles, and calculate changes in volume, Describe the effects of smoking and of lung disease (COPD and lung cancer) on the lungs, [H] Explain how the surface area of alveoli is related to gas exchange.
Exercise P Do you remember?
Method. Move the point one place to the right.
- Multiply. 0.5 x 10 = 5.0.5 x 10 = 5
- Write the answer. 5
Check. 5 divided by 10 is 0.5. ✓
Method. Recall the waste gas of aerobic respiration.
- Recall. Aerobic respiration releases carbon dioxide as a waste product.carbon dioxide
- Write the answer. carbon dioxide
Check. Oxygen is taken in for respiration. ✓
Method. Recall the process.
- Recall. This passive movement down a concentration gradient is diffusion.diffusion
- Write the answer. diffusion
Check. Diffusion is passive. ✓
Method. Recall the wall of a capillary.
- Recall. The wall of a capillary is only one cell thick.one cell thick
- Write the answer. one
Check. The thin wall gives a short diffusion distance. ✓
Method. Work out 10 percent first, then multiply.
- 10 percent. 10% of 50 is 5.5
- Multiply. 40% is 4 x 5 = 20.4 x 5 = 20
- Write the answer. 20
Check. 20 out of 50 is 40%. ✓
The lungs and the airways
Air enters through the nose or mouth, then passes down the trachea (windpipe). The trachea splits into two bronchi, one for each lung. The bronchi split into smaller tubes called bronchioles, which end in clusters of tiny air sacs called alveoli.
The trachea and bronchi are lined with ciliated cells and goblet cells. The goblet cells make mucus, which traps dust and microorganisms. The cilia are tiny hairs that move the mucus up the airway, so it can be swallowed or coughed out.
Key ideas
- Trachea: windpipe, lined with mucus-making goblet cells and cilia.
- Bronchi and bronchioles: smaller airways that carry air to the alveoli.
- Alveoli: tiny air sacs where gas exchange happens.
- Mucus traps dust and microorganisms; cilia move the mucus up and out.
Method. Recall the first tube of the airway.
- Recall. The trachea is the windpipe that carries air down into the chest.windpipe
- Name it. So the tube is the trachea.trachea
- Write the answer. trachea
Check. The trachea splits into two bronchi. ✓
Method. Recall the gas exchange sacs.
- Recall. Gas exchange happens in tiny air sacs at the ends of the bronchioles.air sacs
- Name them. These sacs are the alveoli.alveoli
- Write the answer. alveoli
Check. Alveoli are at the ends of the bronchioles. ✓
Method. Recall the cells and what they do.
- Recall. The cilia are tiny hairs on the ciliated cells that move the mucus.move the mucus
- Name them. So the cells are ciliated cells, and the hairs are cilia.ciliated cells
- Write the answer. ciliated cells; cilia
Check. Goblet cells make the mucus. ✓
Watch out
Watch out: the trachea does not carry gas exchange. Gas exchange happens in the alveoli, at the very end of the airway.
Exam tip
Exam tip. Name the part of the airway and what it does. For a mucus question, mention both the goblet cells and the cilia.
Try it (with your teacher). With your teacher, look at a labelled diagram of the airway. Trace the path of one breath of air from the nose to the alveoli, naming each part.
Exercise 7A The lungs and the airways
Method. Recall the windpipe.
- Recall. The trachea splits into two bronchi, one for each lung.splits into two bronchi
- Write the answer. trachea
Check. The trachea is the windpipe. ✓
Method. Recall the smaller tubes.
- Recall. The bronchi split into smaller tubes called bronchioles.smaller tubes
- Write the answer. bronchioles
Check. The bronchioles end in alveoli. ✓
Method. Recall the mucus-making cells.
- Recall. Goblet cells make mucus, which traps dust and microorganisms.make mucus
- Write the answer. goblet cells
Check. Ciliated cells have the hairs. ✓
Method. Recall the job of cilia.
- Recall. Cilia are tiny hairs that move the mucus up the airway.move the mucus up
- Write the answer. move the mucus
Check. The mucus is swallowed or coughed out. ✓
Method. Recall what the mucus catches.
- Recall. Mucus traps dust and microorganisms that enter the airway.traps dust
- Write the answer. dust and microorganisms
Check. The mucus keeps the lungs clean. ✓
Method. Recall the air sacs.
- Recall. The alveoli are tiny air sacs at the ends of the bronchioles.air sacs
- Write the answer. alveoli
Check. Alveoli are where gas exchange happens. ✓
Method. Follow the airway from the outside in.
- Start. Air enters the trachea first.trachea
- Split. The trachea splits into the bronchi.bronchi
- Branch. The bronchi branch into bronchioles, which end in the alveoli.bronchioles
- Write the answer. trachea, bronchi, bronchioles
Check. The alveoli come after the bronchioles. ✓
Method. Recall the lining of the trachea.
- Recall. The trachea is lined with ciliated cells and goblet cells.lined with
- Write the answer. So yes.yes
- Write the answer. yes
Check. Alveoli have no cilia. ✓
Method. Check where the alveoli are.
- Check. The alveoli are at the ends of the bronchioles, deep in the lungs.ends of the bronchioles
- Conclude. So the statement is not correct.not correct
- Write the answer. Accept any answer that says the alveoli are at the ends of the bronchioles, not in the trachea.
Check. The trachea is only the airway. ✓
Method. Think about what the airway must keep out.
- Think. Dust and microorganisms could damage the lungs.damage the lungs
- Conclude. Mucus traps them, and cilia and coughing remove them.remove them
- Write the answer. Accept any sentence that says it traps harmful particles, so they can be removed by cilia and coughing.
Check. The airway defends the lungs. ✓
Method. Think about how the airway is cleared.
- Think. Coughing forces air out of the airway.forces air out
- Conclude. This moves mucus and particles out of the airway.moves mucus
- Write the answer. Accept coughing, which clears mucus and particles.
Check. Cilia work all the time; coughing is quicker. ✓
Method. Think about what the branching gives.
- Branching. The airways branch many times, ending in many small alveoli.many small alveoli
- Surface. The large number of alveoli gives a large surface for gas exchange.large surface
- Write the answer. Accept any answer that says the many branches give a large number of small air sacs, and so a large surface for gas exchange.
Check. The branching makes a large exchange surface in a small space. ✓
Alveoli and gas exchange
Oxygen diffuses from the air in the alveolus into the blood in the capillaries. Carbon dioxide diffuses the other way, from the blood into the air in the alveolus, to be breathed out. Both gases move down their concentration gradients by diffusion, so no energy is needed.
Alveoli are adapted for this exchange: they have a very large surface area, walls only one cell thick, and a good blood supply that keeps the concentration gradient steep.
| Feature | How it helps diffusion |
|---|---|
| very many tiny alveoli | a large surface area for gas exchange |
| walls one cell thick | a short distance for gases to diffuse |
| surrounded by capillaries | a good blood supply keeps the concentration gradient steep |
| moist lining | gases dissolve before they diffuse |
Key ideas
- Oxygen diffuses from the alveolus into the blood; carbon dioxide diffuses out.
- Alveoli have a large surface area, thin walls, and a good blood supply.
- A good blood supply keeps the concentration gradient steep.
- Gases dissolve in the moist lining before they diffuse.
Method. Recall the gas needed by the cells.
- Recall. Cells need oxygen for aerobic respiration, so it moves into the blood.moves into the blood
- Name it. So the gas is oxygen.oxygen
- Write the answer. oxygen
Check. Carbon dioxide moves the other way. ✓
Method. Recall the adaptations.
- Recall. Alveoli have a large surface area, thin walls and a good blood supply.large surface area
- Choose two. Any two of these are correct.any two
- Write the answer. Accept any two of: large surface area, thin walls, good blood supply.
Check. Each adaptation speeds up diffusion. ✓
Method. Think about the concentration gradient.
- Think. The blood carries oxygen away and brings carbon dioxide.carries oxygen away
- Conclude. So the gradient stays steep, and diffusion continues.stays steep
- Write the answer. The blood carries oxygen away and brings carbon dioxide, so the concentration gradient stays steep.
Check. A steep gradient speeds up diffusion. ✓
Watch out
Watch out: both gases move by diffusion in the same place. Oxygen goes into the blood, and carbon dioxide goes out of the blood, so do not say that one moves by active transport.
Exam tip
Exam tip. When you explain an adaptation, say what it does and why that helps. “Thin walls” alone does not earn the mark.
Try it (with your teacher). With your teacher, look at a labelled diagram of an alveolus. Draw it, and add arrows for oxygen and carbon dioxide, with a label for each adaptation.
Exercise 7B Alveoli and gas exchange
Method. Recall the gas taken into the blood.
- Recall. Oxygen diffuses from the alveoli into the blood.into the blood
- Write the answer. oxygen
Check. Oxygen is used in respiration. ✓
Method. Recall the waste gas.
- Recall. Carbon dioxide diffuses from the blood into the alveoli.from the blood into the alveoli
- Write the answer. carbon dioxide
Check. Carbon dioxide is breathed out. ✓
Method. Recall the process.
- Recall. Gases move down their concentration gradients by diffusion.down their concentration gradients
- Write the answer. diffusion
Check. Diffusion needs no energy. ✓
Method. Recall the structure.
- Recall. There are very many tiny alveoli in each lung.very many tiny
- Name it. So the large number of alveoli gives a large surface area.large surface area
- Write the answer. Accept many alveoli, or a very large number of tiny sacs.
Check. The small size is also important. ✓
Method. Recall the wall structure.
- Recall. Alveolus walls are only one cell thick.only one cell thick
- Write the answer. one cell thick
Check. A thin wall gives a short distance. ✓
Method. Recall the blood vessels.
- Recall. Capillaries surround each alveolus, so the blood is close to the air.close to the air
- Write the answer. capillaries
Check. Capillaries carry blood close to the air. ✓
Method. Recall whether diffusion uses energy.
- Recall. Diffusion is a passive process and needs no energy.passive
- Write the answer. So no.no
- Write the answer. no
Check. Breathing in does use muscles, which is a different process. ✓
Method. Recall the lining of the alveolus.
- Recall. The alveolus has a thin moist lining in which gases dissolve.moist lining
- Name it. So the answer is the moist lining.moist lining
- Write the answer. Accept the moist lining.
Check. Gases must dissolve before they diffuse. ✓
Method. Think about the gradient.
- Think. Blood is carried away, so its oxygen level stays lower than in the alveolus.stays lower
- Conclude. So oxygen keeps diffusing from the alveolus into the blood.keeps diffusing
- Write the answer. Accept any sentence that says the blood is constantly carried away, so its oxygen level stays lower than the alveolus.
Check. The gradient is kept by the blood flow. ✓
Method. Think about the wall and diffusion.
- Check. The walls of the alveoli are one cell thick.one cell thick
- Conclude. A thin wall gives a short distance, so diffusion is faster.short distance
- Write the answer. Accept any sentence that says the walls are thin, so the distance for diffusion is short.
Check. Thick walls would slow the diffusion. ✓
Method. Link the blood supply to the gradient.
- Gradient. The blood supply carries oxygen away and brings carbon dioxide, keeping the gradient steep.keeping the gradient steep
- Continue. Fresh blood keeps arriving, so exchange can continue.fresh blood
- Conclude. A large surface alone would not work without a good blood supply.alone would not work
- Write the answer. Accept any answer that says the blood supply carries gases away, keeping the gradient steep, and replaces the blood so exchange continues.
Check. Surface and gradient work together. ✓
Breathing and ventilation
Breathing in (inhalation): the diaphragm contracts and flattens, and the intercostal muscles between the ribs contract, lifting the ribs up and out. The volume of the chest increases, so the pressure falls and air flows in.
Breathing out (exhalation): normally this is passive. The diaphragm relaxes and domes up, and the intercostal muscles relax, so the ribs move down and in. The volume decreases, the pressure rises, and air flows out.
Key ideas
- Breathing in: the diaphragm flattens and the ribs move up and out.
- Breathing out: the diaphragm domes up and the ribs move down and in.
- When the volume increases, the pressure falls and air flows in.
- Breathing out at rest is passive; it needs no muscle contraction.
Method. Recall the muscle under the lungs.
- Recall. The diaphragm is the muscle below the lungs that contracts when breathing in.below the lungs
- Name it. So the muscle is the diaphragm.diaphragm
- Write the answer. diaphragm
Check. The intercostal muscles are between the ribs. ✓
Method. Find 3 seconds on the time axis, then read the volume.
- Find 3. Find 3 seconds on the x-axis.3 s
- Read. The volume at 3 seconds is 3.4 dm3.3.4
- Write the answer. 3.4
Check. 3.4 is the highest value in the graph. ✓
Method. Subtract the volume at 0 seconds from the volume at 3 seconds.
- Read. The volume is 2.5 dm3 at 0 seconds and 3.4 dm3 at 3 seconds.2.5 and 3.4
- Subtract. The change is 3.4 - 2.5 = 0.9 dm3.3.4 - 2.5 = 0.9
- Write the answer. 0.9
Check. 2.5 + 0.9 = 3.4. ✓
Watch out
Watch out: breathing in is active (muscles contract), but breathing out at rest is passive (muscles relax). Do not say that the diaphragm pushes air out at rest.
Exam tip
Exam tip. When you describe breathing in, say which muscle contracts and what happens to the volume and pressure.
Try it (with your teacher). Lie on your back with your hands on your ribs and belly. Breathe in gently, then out. Describe in one sentence what happens to your ribs and your belly. Do not hold your breath.
Exercise 7C Breathing and ventilation
Method. Recall the breathing muscle.
- Recall. The diaphragm contracts and flattens when you breathe in.contracts and flattens
- Write the answer. diaphragm
Check. The diaphragm is below the lungs. ✓
Method. Recall the muscles between the ribs.
- Recall. The muscles between the ribs are the intercostal muscles.intercostal muscles
- Write the answer. intercostal muscles
Check. They move the ribs up and out or down and in. ✓
Method. Recall the movement when breathing in.
- Recall. The intercostal muscles contract and lift the ribs up and out.up and out
- Write the answer. up and out
Check. Down and in is for breathing out. ✓
Method. Recall the effect of the muscles.
- Recall. The diaphragm flattens and the ribs move out, so the chest volume increases.chest volume increases
- Write the answer. increase
Check. When the volume increases, the pressure falls. ✓
Method. Think about pressure and volume.
- Think. When the volume increases, the pressure falls.pressure falls
- Write the answer. fall
Check. Air then flows in from high pressure outside. ✓
Method. Recall how breathing out happens at rest.
- Recall. At rest, the muscles relax and the lungs recoil, so breathing out is passive.muscles relax
- Write the answer. passive
Check. Breathing in at rest is active. ✓
Method. Read the first point.
- Read. The graph starts at 2.5 dm3 at 0 seconds.2.5
- Write the answer. 2.5
Check. The lowest value is also 2.5 at 6 seconds. ✓
Method. Find the lowest point.
- Find. The lowest point is 2.5 dm3, at 0 and 6 seconds.2.5
- Write the answer. 2.5
Check. The highest is 3.4 dm3. ✓
Method. Subtract the two readings.
- Read. The volume is 3.4 dm3 at 3 seconds and 2.5 dm3 at 6 seconds.3.4 and 2.5
- Subtract. The change is 3.4 - 2.5 = 0.9 dm3, a decrease.3.4 - 2.5 = 0.9
- Write the answer. 0.9
Check. 2.5 + 0.9 = 3.4. ✓
Method. Think about the muscles when breathing out.
- Muscles. The diaphragm domes up and the intercostal muscles relax.domes up
- Volume. So the ribs move down and in, and the volume decreases.volume decreases
- Write the answer. Accept any sentence that says the volume decreases as the diaphragm domes up and the ribs move down and in.
Check. Breathing out lowers the volume and raises the pressure. ✓
Method. Link the volume, pressure and movement of air.
- Volume. The volume of the chest increases when breathing in.volume increases
- Pressure. So the pressure inside falls below the outside air pressure.pressure falls
- Movement. Air moves from high to low pressure, into the lungs.into the lungs
- Write the answer. Accept any sentence that says the volume increases, so the pressure falls below the outside pressure, and air moves in.
Check. Air moves from high to low pressure. ✓
Method. Describe the mechanism more accurately.
- Muscle. The diaphragm contracts and changes the volume of the chest.changes the volume
- Air. It is the lower pressure in the chest that moves the air in, not the muscle pulling air directly.lower pressure
- Conclude. So the muscle works by changing volume and pressure.changing volume
- Write the answer. Accept any answer that says the muscle changes the volume of the chest, and the pressure difference moves the air in.
Check. Volume and pressure link the muscle to the air. ✓
Smoking and lung disease
Smoking damages the lungs in several ways. Tar from the smoke coats the alveoli and the airways, and the cilia are paralysed and killed, so mucus builds up and cannot be cleared. Carbon monoxide binds to haemoglobin, reducing the amount of oxygen that the blood can carry. Smoking can lead to COPD (chronic obstructive pulmonary disease), which narrows the airways and damages the alveoli, and to lung cancer, when cells in the lungs divide uncontrollably.
| Cigarettes per day (invented data) | Lung disease cases per 100 people |
|---|---|
| 0 | 1 |
| 5 | 3 |
| 10 | 6 |
| 20 | 12 |
| Disease | What happens to the lungs | Link to smoking |
|---|---|---|
| COPD (chronic obstructive pulmonary disease) | airways are narrowed; alveoli are damaged | a major cause |
| lung cancer | cells in the lungs divide uncontrollably | a major cause |
| emphysema (part of COPD) | alveolar walls break down, so the surface area is reduced | a major cause |
Key ideas
- Tar coats the airways and alveoli, and damages the cilia.
- Carbon monoxide reduces the amount of oxygen the blood carries.
- COPD narrows the airways and damages the alveoli.
- Lung cancer is uncontrolled cell division in the lungs.
Method. Find the bar for 20 cigarettes.
- Find. The bar for 20 cigarettes a day is the tallest bar.tallest bar
- Read. It shows 12 cases per 100 people.12
- Write the answer. 12
Check. The table gives the same figure. ✓
Method. Subtract the two counts.
- Read. There are 12 cases at 20 cigarettes and 1 at 0.12 and 1
- Subtract. The difference is 12 - 1 = 11 cases per 100 people.12 - 1 = 11
- Write the answer. 11
Check. 1 + 11 = 12. ✓
Method. Recall the disease.
- Recall. COPD narrows the airways and damages the alveoli.narrows the airways
- Name it. So the disease is chronic obstructive pulmonary disease (COPD).COPD
- Write the answer. chronic obstructive pulmonary disease (COPD)
Check. COPD is linked to smoking. ✓
Watch out
Watch out: the data show an association between smoking and lung disease, not a proof on their own. The data are invented here, and you must always say what the data do and do not show.
Exam tip
Exam tip. When you read a data set, quote one value from the table or graph. Say what it shows, then how far it supports the conclusion.
Try it (with your teacher). With your teacher, find out how a block of cards with a mock tar stain would affect a model of the airway. Do not use real tobacco. Describe what the model shows.
Exercise 7D Smoking and lung disease
Method. Recall the substance.
- Recall. Tar from smoke coats the airways and the alveoli.coats
- Write the answer. tar
Check. Carbon monoxide is a different substance. ✓
Method. Recall the gas.
- Recall. Carbon monoxide binds to haemoglobin, so less oxygen is carried.binds to haemoglobin
- Write the answer. carbon monoxide
Check. Less oxygen is carried by the blood. ✓
Method. Recall the effect on the cilia.
- Recall. Smoke paralyses the cilia and kills them.paralyses
- Write the answer. paralyses and kills them
Check. Mucus then builds up in the airways. ✓
Method. Recall the disease.
- Recall. COPD narrows the airways and damages the alveoli.narrows the airways
- Write the answer. COPD
Check. COPD stands for chronic obstructive pulmonary disease. ✓
Method. Recall what cancer is.
- Recall. Lung cancer is cells dividing uncontrollably.dividing uncontrollably
- Write the answer. uncontrolled cell division
Check. Cancer forms a mass of cells. ✓
Method. Read the table.
- Read. The row for 10 cigarettes a day shows 6 cases.6
- Write the answer. 6
Check. 6 is double the value for 5 cigarettes. ✓
Method. Subtract the two values.
- Read. At 5 cigarettes there are 3 cases, and at 0 there is 1 case.3 and 1
- Subtract. The difference is 3 - 1 = 2.3 - 1 = 2
- Write the answer. 2
Check. 1 + 2 = 3. ✓
Method. Look at the trend across the bars.
- Look. The bars rise from 1 to 3 to 6 to 12 as the cigarettes per day rise.rise from 1 to 12
- Write the answer. So yes, the number of cases rises with cigarettes per day.yes
- Write the answer. yes
Check. This is an association in invented data. ✓
Method. Check the claim against the data.
- Check. The data show that more smoking is linked to more cases, not that every smoker gets the disease.linked to more cases
- Conclude. So the claim goes further than the data, and the answer is no.goes further
- Write the answer. Accept any answer that says the data show an association, and not every smoker gets the disease.
Check. Association is not the same as certainty. ✓
Method. Think about how carbon monoxide acts.
- Think. Carbon monoxide binds more strongly to haemoglobin than oxygen does.binds to haemoglobin
- Conclude. So less oxygen can be carried by the red blood cells.less oxygen
- Write the answer. Accept any sentence that says carbon monoxide binds to haemoglobin, so less oxygen is carried.
Check. Less oxygen means less energy for the body. ✓
Method. Link the damage to the breathing.
- Airways. COPD narrows the airways, making air hard to move out.hard to move out
- Alveoli. Damaged alveoli are less elastic, so they do not recoil as well.recoil
- Conclude. So air is trapped and breathing out is difficult.trapped
- Write the answer. Accept any answer that says the airways are narrowed, and the alveoli damaged, so air is trapped and cannot be breathed out easily.
Check. Narrowed airways and damaged alveoli both reduce the flow out. ✓
Alveolar surface area and gas exchange [H]
[H] Higher tier only. This section is higher-tier content. It uses invented numbers for practice, to show how the surface area of many small sacs adds up.
The total surface area of the alveoli is found by multiplying the number of alveoli by the surface area of one alveolus. Many small sacs give a very large total area, which is what the lungs need for gas exchange.
Because the alveoli are so small and so many, the total surface area is far larger than the body surface. This is why the lungs can take in enough oxygen for the whole body.
| Feature | How it helps diffusion |
|---|---|
| very many tiny alveoli | a large surface area for gas exchange |
| walls one cell thick | a short distance for gases to diffuse |
| surrounded by capillaries | a good blood supply keeps the concentration gradient steep |
| moist lining | gases dissolve before they diffuse |
Key ideas
- [H] Total surface area = number of alveoli x surface area of one alveolus.
- [H] Many small alveoli give a large total surface area.
- [H] A larger surface area allows more diffusion in a given time.
- [H] The surface area is limited by disease: damaged alveoli have less surface.
Method. Multiply the number of alveoli by the area of one alveolus.
- Multiply. Total = 200 x 4.200 x 4
- Calculate. 200 x 4 = 800 mm2.800
- Write the answer. 800
Check. 800 divided by 200 is 4 mm2. ✓
Method. Recalculate with the new number of alveoli.
- New number. The number of alveoli is now 100.100
- Calculate. New total = 100 x 4 = 400 mm2.400
- Write the answer. 400
Check. Half the alveoli gives half the total area. ✓
Method. Think about the surface area.
- Think. Damage reduces the number of alveoli and the surface area.reduces the surface area
- Conclude. Less surface means less diffusion of oxygen and carbon dioxide.less diffusion
- Write the answer. Damage reduces the surface area, so less oxygen and carbon dioxide can diffuse.
Check. A smaller surface means slower diffusion. ✓
Watch out
Watch out: a bigger total surface area is the result of many small alveoli, not one big one. Do not multiply the number of alveoli by the area of the whole lung.
Exam tip
Exam tip. [H] Check the units of the final answer. An area in mm2 stays in mm2 when you multiply by a number of alveoli.
Try it (with your teacher). With your teacher, use a drawing of a sponge or a bunch of grapes to show how many small pieces give a large total surface. Describe what happens to the total surface if the pieces are made larger.
Exercise 7E [H] Alveolar surface area and gas exchange
Method. Recall the method.
- Recall. The total is the number of alveoli multiplied by the area of one alveolus.multiplied by
- Write the answer. number of alveoli x surface area of one alveolus
Check. Multiply, not add. ✓
Method. Multiply the two numbers.
- Multiply. 50 x 2 = 100.50 x 2 = 100
- Write the answer. 100
Check. 100 divided by 50 is 2. ✓
Method. Multiply the number by the area.
- Multiply. 200 x 4 = 800.200 x 4 = 800
- Write the answer. 800
Check. 800 divided by 4 is 200. ✓
Method. Multiply the number by the area.
- Multiply. 300 x 3 = 900.300 x 3 = 900
- Write the answer. 900
Check. 900 divided by 3 is 300. ✓
Method. Work out the area that remains.
- Remaining. Only 100 alveoli remain, each with an area of 4 mm2.100 x 4
- Calculate. 100 x 4 = 400 mm2.400
- Write the answer. Accept 400.
Check. Half the alveoli give half the area. ✓
Method. Compare the shapes.
- Compare. Many small sacs have more outside surface than one large sac with the same volume.more outside surface
- Conclude. So the same space gives more surface for exchange.more surface
- Write the answer. Accept any sentence that says the small sacs give more surface for the same space.
Check. Dividing a volume into smaller parts increases the total surface. ✓
Method. Check the total against one alveolus.
- Check. The total is the number of alveoli times the area of one, so it is much larger.much larger
- Conclude. So the answer is no.no
- Write the answer. Accept any answer that says there are many alveoli, so the total is many times larger.
Check. Multiply by the number of alveoli. ✓
Method. Link the surface area to the rate of diffusion.
- Surface. Emphysema destroys alveoli, so the total surface area falls.total surface area falls
- Diffusion. Less surface means less oxygen can diffuse into the blood each second.less oxygen
- Conclude. So the rate of oxygen uptake falls.rate of oxygen uptake falls
- Write the answer. Accept any answer that says less surface area means less diffusion, so less oxygen reaches the blood.
Check. The surface area sets the limit on diffusion. ✓
Chapter summary
| Skill | Method |
|---|---|
| Airway | Trachea, bronchi, bronchioles, alveoli; goblet cells make mucus and cilia move it. |
| Alveoli | Large surface area, walls one cell thick, a good blood supply and a moist lining. |
| Breathing in | Diaphragm flattens and ribs move up and out; volume increases; pressure falls. |
| Breathing out | Diaphragm domes up and ribs move down and in; volume decreases; pressure rises. |
| Smoking | Tar damages the airways and cilia; carbon monoxide reduces oxygen carried by the blood. |
| COPD and lung cancer | COPD narrows the airways and damages the alveoli; lung cancer is uncontrolled cell division. |
| [H] Surface area | Total = number of alveoli x surface area of one alveolus. |
Can you…?
- I can name the parts of the airway and say what each does
- I can explain how alveoli are adapted for gas exchange
- I can describe breathing in and out, using the diaphragm and intercostal muscles
- I can interpret data on smoking and lung disease
- [H] I can calculate a total surface area from the number and size of alveoli
Key terms
- trachea
- the windpipe, which carries air to the bronchi
- bronchus
- one of the two tubes that carry air into each lung
- bronchiole
- a small airway that ends in alveoli
- alveolus
- a tiny air sac in the lungs where gas exchange happens
- cilia
- tiny hairs that move mucus up the airway
- goblet cell
- a cell that makes mucus in the airway
- diaphragm
- a muscle below the lungs that changes the volume of the chest
- intercostal muscles
- muscles between the ribs that move the ribs when breathing
- COPD
- chronic obstructive pulmonary disease, which narrows the airways and damages the alveoli
- [H] total surface area
- the number of alveoli multiplied by the surface area of one alveolus
Exercise 7Z Check-up
Method. Recall the windpipe.
- Recall. The trachea carries air down into the chest.down into the chest
- Write the answer. trachea
Check. The trachea is also called the windpipe. ✓
Method. Recall the air sacs.
- Recall. Gas exchange happens in the alveoli.Gas exchange
- Write the answer. alveoli
Check. Alveoli are at the ends of the bronchioles. ✓
Method. Recall the muscle.
- Recall. The diaphragm contracts and flattens when breathing in.flattens
- Write the answer. diaphragm
Check. The diaphragm is below the lungs. ✓
Method. Recall the waste gas.
- Recall. Carbon dioxide diffuses from the blood into the alveoli.from the blood
- Write the answer. carbon dioxide
Check. Oxygen moves the other way. ✓
Method. Recall the disease.
- Recall. COPD narrows the airways and damages the alveoli.narrows the airways
- Write the answer. COPD
Check. COPD is linked to smoking. ✓
Method. Recall the adaptations.
- Recall. Alveoli have a large surface area, thin walls and a good blood supply.thin walls
- Choose one. Any one is correct.any one
- Write the answer. Accept any one: a large surface area, thin walls, or a good blood supply.
Check. Each one speeds up diffusion. ✓
Method. Read the graph at 3 seconds.
- Read. At 3 seconds the volume is 3.4 dm3.3.4
- Write the answer. 3.4
Check. It is the highest point on the graph. ✓
Method. Divide the number with disease by the total, then multiply by 100.
- Divide. 12 / 40 = 0.3.12 / 40 = 0.3
- Multiply. Multiply by 100 to give 30%.30%
- Write the answer. 30%
Check. 30% of 40 is 12. ✓
Method. Describe the muscles and the volume.
- Muscles. The diaphragm domes up and the intercostal muscles relax.domes up
- Volume. The volume of the chest decreases.decreases
- Write the answer. Accept any sentence that says the volume decreases as the diaphragm domes up and the ribs move down and in.
Check. The pressure rises and air flows out. ✓
Method. Describe each cell type.
- Goblet. Goblet cells make mucus that traps dust and microorganisms.traps
- Cilia. Cilia move the mucus up and away from the lungs.move the mucus
- Write the answer. Accept any sentence that says goblet cells make mucus that traps particles, and cilia move it away from the lungs.
Check. Both are needed to keep the airway clean. ✓
Total 24 marks. Allow about 24 minutes.
Exercise 7X Exam-style questions
Method. Recall the process.
- Recall. Oxygen moves by diffusion from the alveoli into the blood.by diffusion
- Write the answer. diffusion
Check. Diffusion is passive. ✓
Method. Recall the muscle.
- Recall. The diaphragm relaxes and domes up when breathing out.domes up
- Write the answer. diaphragm
Check. The intercostal muscles also relax. ✓
Method. Recall the disease.
- Recall. Uncontrolled cell division in the lungs is lung cancer.uncontrolled cell division
- Write the answer. lung cancer
Check. Lung cancer is linked to smoking. ✓
Method. Give two adaptations.
- Adaptation 1. The alveoli have a large surface area from their very many tiny sacs.large surface area
- Adaptation 2. The walls are one cell thick, giving a short diffusion distance.one cell thick
- Write the answer. Accept any two of: a large surface area, thin walls, a good blood supply, a moist lining.
Check. Each adaptation must be linked to diffusion. ✓
Method. Describe the muscles, then the volume and pressure.
- Muscles. The diaphragm contracts and flattens, and the intercostal muscles contract.contracts and flattens
- Ribs. The ribs move up and out.up and out
- Volume. The volume increases and the pressure falls, so air flows in.pressure falls
- Write the answer. Accept any three of: the diaphragm contracts and flattens; the intercostal muscles contract; the ribs move up and out; the volume increases; the pressure falls.
Check. Breathing in is active. ✓
Method. Follow the damage from smoke to disease.
- Tar. Tar from smoke coats and damages the airways.coats and damages
- Cilia. The cilia are damaged, so mucus builds up.mucus builds up
- Alveoli. The airways narrow, and the alveoli are damaged, reducing gas exchange.reducing gas exchange
- Write the answer. Accept any three of: tar coats and damages the airways; cilia are damaged and mucus builds up; the airways narrow; the alveoli are damaged.
Check. Each point describes damage from smoke. ✓
Method. Divide the larger value by the smaller one.
- Divide. 12 / 6 = 2.12 / 6 = 2
- Write the answer. 2
Check. 6 x 2 = 12. ✓
Method. Subtract, then decide the direction from the volume.
- Change. 3.4 - 2.5 = 0.9 dm3.3.4 - 2.5 = 0.9
- Direction. The volume increased, so this is a breath in.breath in
- Write the answer. Accept 0.9 dm3, breath in.
Check. A breath out makes the volume fall. ✓
Method. Describe the trend, then the limit.
- Trend. The number of cases rises from 1 to 12 per 100 as cigarettes per day rise from 0 to 20.rises from 1 to 12
- Association. This shows an association between smoking and lung disease.association
- Limit. The data cannot prove smoking alone causes the disease, because other factors may be involved.cannot prove
- Write the answer. Accept any answer that says the cases rise with cigarettes per day, but the data show an association and cannot prove that smoking alone causes the disease.
Check. Quote values, then state the limit. ✓
Method. Calculate, then explain the effect of damage.
- Total. Total = 300 x 3 = 900 mm2.300 x 3 = 900
- Damage. Damage reduces the number of alveoli.reduces the number
- Effect. The total surface area then falls.total surface area falls
- Diffusion. Less surface means less oxygen and carbon dioxide can diffuse each second.less oxygen
- Conclude. So damage reduces gas exchange, and breathing becomes harder.reduces gas exchange
- Write the answer. Accept 900 mm2, and an answer that says damage reduces the number of alveoli, so the total surface falls.
Check. Check the multiplication: 900 divided by 3 is 300. ✓